AustralieFrV1, Main, Exploration, bibRecord, 007999

Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal

Identifieur interne : 007999 ( Main/Exploration ); précédent : 007998; suivant : 007A00

Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal

Auteurs : Truong D. Nguyen-Huu [Australie] ; César Mattei [France] ; Peter J. Wen [Australie] ; Andrea J. Bourdelais [États-Unis] ; Richard J. Lewis [Australie] ; Evelyne Benoit [France] ; Daniel G. Baden [États-Unis] ; Jordi Molgo [France] ; Frédéric A. Meunier [Australie]

Source :

Toxicon : (Oxford) [ 0041-0101 ] ; 2010.

RBID : Pascal:10-0467266

Descripteurs français

Pascal (Inist)
- Ciguatoxine, Catécholamine, Sécrétion, Bovin, Animal, Cellule chromaffine, Mécanisme action, Inhibition, Ciguatera, Dinophyta, Neurotoxine, Ion sodium, Sodium, Canal ionique, Exocytose, Vésicule, Brevetoxine.
Wicri :
- topic : Bovin, Sodium.

English descriptors

KwdEn :
- Animal, Bovine, Brevetoxin, Catecholamine, Chromaffin cell, Ciguatera, Dinophyta, Exocytosis, Inhibition, Ionic channel, Mechanism of action, Neurotoxin, Secretion, Sodium, Sodium ion, Vesicle.

Abstract

Ciguatoxin (P-CTX-1B) from the dinoflagellate Gambierdiscus toxicus, belongs to the family of polyether neurotoxins responsible for the neurological poisoning disorder ciguatera. Although it is the most widespread marine-borne disease affecting humans, there is no current FDA-approved treatment available except for symptomatic therapies. In this paper, we report that P-CTX-1B promotes catecholamine secretion from bovine chromaffin cells, an effect that is insensitive to concomitant activation of capacitative Ca²⁺ entry. Moreover, we confirm that brevenal, a polyether from the dinoflagellate Karenia brevis, blocks P-CTX-1B-induced catecholamine secretion. This effect is partially reversible. Our results therefore raise the prospect of finding functional antagonists for P-CTX-1B that could be useful for the treatment of ciguatera.

Affiliations:

Australie, France, États-Unis

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Bovine</term>
<term>Brevetoxin</term>
<term>Catecholamine</term>
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<term>Ciguatera</term>
<term>Dinophyta</term>
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<front><div type="abstract" xml:lang="en">Ciguatoxin (P-CTX-1B) from the dinoflagellate Gambierdiscus toxicus, belongs to the family of polyether neurotoxins responsible for the neurological poisoning disorder ciguatera. Although it is the most widespread marine-borne disease affecting humans, there is no current FDA-approved treatment available except for symptomatic therapies. In this paper, we report that P-CTX-1B promotes catecholamine secretion from bovine chromaffin cells, an effect that is insensitive to concomitant activation of capacitative Ca<sup>2+</sup>
 entry. Moreover, we confirm that brevenal, a polyether from the dinoflagellate Karenia brevis, blocks P-CTX-1B-induced catecholamine secretion. This effect is partially reversible. Our results therefore raise the prospect of finding functional antagonists for P-CTX-1B that could be useful for the treatment of ciguatera.</div>
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Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal

Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri